Format

Send to

Choose Destination
Nat Prod Rep. 2013 Mar;30(3):382-91. doi: 10.1039/c3np20122h. Epub 2013 Jan 21.

Polycyclic xanthone natural products: structure, biological activity and chemical synthesis.

Author information

1
Department of Chemistry, Center for Chemical Methodology and Library Development (CMLD-BU), Boston University, 590 Commonwealth Avenue, Boston, MA 02215, USA.

Abstract

Polycyclic xanthone natural products are a family of polyketides which are characterized by highly oxygenated, angular hexacyclic frameworks. In the last decade, this novel class of molecules has attracted noticeable attention from the synthetic and biological communities due to emerging reports of their potential use as antitumour agents. The aim of this article is to highlight the most recent developments of this subset of the xanthone family by detailing the innate challenges of the construction of this class of natural products, new synthetic approaches, and pharmacological data.

PMID:
23334431
PMCID:
PMC3615431
DOI:
10.1039/c3np20122h
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Royal Society of Chemistry Icon for PubMed Central
Loading ...
Support Center