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Biochim Biophys Acta. 2013 Aug;1836(1):80-9. doi: 10.1016/j.bbcan.2013.01.001. Epub 2013 Jan 17.

More than two decades of Apc modeling in rodents.

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1
Department of Molecular Biosciences, University of Kansas, 1200 Sunnyside Ave., Lawrence, KS 66045, USA.

Abstract

Mutation of tumor suppressor gene adenomatous polyposis coli (APC) is an initiating step in most colon cancers. This review summarizes Apc models in mice and rats, with particular concentration on those most recently developed, phenotypic variation among different models, and genotype/phenotype correlations.

PMID:
23333833
PMCID:
PMC3655098
DOI:
10.1016/j.bbcan.2013.01.001
[Indexed for MEDLINE]
Free PMC Article
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