Format

Send to

Choose Destination
Semin Cell Dev Biol. 2013 Apr;24(4):298-307. doi: 10.1016/j.semcdb.2012.12.004. Epub 2013 Jan 16.

The regulation and functional impact of actin assembly at cadherin cell-cell adhesions.

Author information

1
Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, Queensland 4072, Australia. m.michael@imb.uq.edu.au

Abstract

Cadherin adhesion receptors are critical components for the maintenance of tissue architecture and organisation during development and in post-embryonic life. These receptors influence the actin cytoskeletal network by controlling its assembly at the junctions. Likewise, the actin cytoskeleton is required for cadherin integrity at cell-cell contacts. The junctional cytoskeleton is intrinsically dynamic and undergoes constant assembly and reorganisation to maintain a morphologically stable structure. This is governed by a host of molecular players that regulate actin assembly during nucleation and at post-nucleation stages. This review highlights the molecular machinery implicated in actin organisation at various stages of junctional assembly and its functional impact in simple epithelia and other model systems.

PMID:
23333496
DOI:
10.1016/j.semcdb.2012.12.004
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center