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Mitochondrion. 2013 Mar;13(2):106-18. doi: 10.1016/j.mito.2013.01.003. Epub 2013 Jan 16.

Mitochondrial dysfunction and the inflammatory response.

Author information

1
Aging and Inflammation Research Laboratory, Instituto de Investigación Biomédica A Coruña (INIBIC)-Complexo Hospitalario Universitario A Coruña (CHUAC)-SERGAS, Xubias 84, 15006, A Coruña, Spain. Maria.Jose.Lopez.Armada@sergas.es

Abstract

Inflammation has been linked to multiple degenerative and acute diseases as well as the aging process. Moreover, mitochondrial alterations play a central role in these processes. Mitochondria have an important role in pro-inflammatory signaling; similarly, pro-inflammatory mediators may also alter mitochondrial function. Both of these processes increase mitochondrial oxidative stress, promoting a vicious inflammatory cycle. Additionally, damage-associated molecular patterns derived from mitochondria could contribute to inflammasome formation and caspase-1 activation, while alterations in mitochondrial autophagy may cause inflammation. Strategies aimed at controlling excessive oxidative stress within mitochondria may represent both preventive and therapeutic interventions in inflammation.

PMID:
23333405
DOI:
10.1016/j.mito.2013.01.003
[Indexed for MEDLINE]

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