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Cell. 2013 Jan 17;152(1-2):17-24. doi: 10.1016/j.cell.2012.12.024.

A decade of riboswitches.

Author information

1
Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA. alexander.serganov@nyumc.org

Abstract

Riboswitches were discovered in 2002 in bacteria as RNA-based intracellular sensors of vitamin derivatives. During the last decade, naturally occurring RNA sensor elements have been found to bind a range of small metabolites and ions and to exert regulatory control of transcription, translation, splicing, and RNA stability. Extensive biochemical, structural, and genetic studies have established the basic principles underpinning riboswitch function in all three kingdoms of life with implications for developing antibiotics, designing new molecular sensors, and integrating riboswitches into synthetic circuits.

PMID:
23332744
PMCID:
PMC4215550
DOI:
10.1016/j.cell.2012.12.024
[Indexed for MEDLINE]
Free PMC Article

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