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Gastroenterol Hepatol. 2013 Feb;36(2):104-14. doi: 10.1016/j.gastrohep.2012.09.006. Epub 2013 Jan 14.

Therapeutic guidelines on ulcerative colitis: a GRADE methodology based effort of GETECCU.

Author information

1
Department of Gastroenterology, Hospital Clínico Universitario Lozano Blesa, Instituto de Investigación Sanitaria, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Zaragoza, Spain. fgomollon@gmail.com

Abstract

BACKGROUND AND AIM:

Evidence-based clinical guidelines on Ulcerative colitis (UC) have been developed through a consensus, while GRADE methodology is the current standard for guideline development. This is the first one based on GRADE methodology on UC.

METHODS:

Following GRADE methodology, the Spanish Group of Ulcerative Colitis and Crohn's disease (GETECCU) have developed a guideline on UC treatment. After selection of relevant clinical scenarios, 32 clinical questions were chosen and recommendations were established.

RESULTS:

In 2 questions no recommendation was possible. Twenty-two actions were recommended for, 14 strongly and 8 weakly. However, in 8 questions a recommendation against doing something was obtained, weak in 5 and strong in 3. The majority of recommendations were based on moderate quality evidence, and only 5 on high-quality evidence.

CONCLUSIONS:

With GRADE methodology we find a clear recommendation on possible actions in most clinical decisions in UC treatment, but much more clinical high-quality research is needed.

PMID:
23332546
DOI:
10.1016/j.gastrohep.2012.09.006
[Indexed for MEDLINE]

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