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Leuk Res. 2013 May;37(5):503-9. doi: 10.1016/j.leukres.2012.12.013. Epub 2013 Jan 17.

Adipose tissue attracts and protects acute lymphoblastic leukemia cells from chemotherapy.

Author information

1
Center for Endocrinology, Diabetes & Metabolism, Children's Hospital Los Angeles, CA, USA.

Abstract

Obesity is associated with an increased risk of acute lymphoblastic leukemia (ALL) relapse. Using mouse and cell co-culture models, we investigated whether adipose tissue attracts ALL to a protective microenvironment. Syngeneically implanted ALL cells migrated into adipose tissue within ten days. In vitro, murine ALL cells migrated towards adipose tissue explants and 3T3-L1 adipocytes. Human and mouse ALL cells migrated toward adipocyte conditioned media, which was mediated by SDF-1α. In addition, adipose tissue explants protected ALL cells against daunorubicin and vincristine. Our findings suggest that ALL migration into adipose tissue could contribute to drug resistance and potentially relapse.

PMID:
23332453
PMCID:
PMC3622767
DOI:
10.1016/j.leukres.2012.12.013
[Indexed for MEDLINE]
Free PMC Article

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