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Curr Opin Chem Biol. 2013 Feb;17(1):27-33. doi: 10.1016/j.cbpa.2012.11.008. Epub 2013 Jan 14.

Emerging roles for protein S-palmitoylation in immunity from chemical proteomics.

Author information

1
Laboratory of Chemical Biology and Microbial Pathogenesis, The Rockefeller University, New York, NY 10065, United States.

Abstract

The activation of innate and adaptive immune signaling pathways and effector functions often occur at cellular membranes and are regulated by complex mechanisms. Here we review the growing number of proteins which are known to be regulated by S-palmitoylation in immune cells emerging from recent advances in chemical proteomics. These chemical proteomic studies have highlighted the roles of this dynamic lipid modification in regulating the specificity and strength of immune responses in different lymphocyte populations.

PMID:
23332315
PMCID:
PMC4000526
DOI:
10.1016/j.cbpa.2012.11.008
[Indexed for MEDLINE]
Free PMC Article

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