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Org Lett. 2013 Feb 1;15(3):639-41. doi: 10.1021/ol303348m. Epub 2013 Jan 18.

Tritylamine as an ammonia surrogate in the Ugi tetrazole synthesis.

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1
Department for Drug Design, University of Groningen, A. Deusinglaan 1, Groningen 9713AV, The Netherlands.

Abstract

The role of tritylamine is introduced as a convenient ammonia substitute in the Ugi tetrazole synthesis. Fifteen examples and their mild cleavage products are described in satisfactory to good yields. N-Unsubstituted α-aminotetrazoles are important compounds with annotated biological activities, and the described two-step synthesis provided an alternative route to otherwise difficult to access derivatives.

PMID:
23331054
DOI:
10.1021/ol303348m
[Indexed for MEDLINE]
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