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Comb Chem High Throughput Screen. 2013 Jun 1;16(5):345-93.

Nitrogen containing privileged structures and their solid phase combinatorial synthesis.

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Pharmacy Department, Faculty of Technology & Engineering, The M S University of Baroda, Kala Bhavan, Vadodara-390001, Gujarat, India.


The existence of preferred molecular scaffolds that possess inherent biological activity, called privileged structures, is now well recognized. Such privileged structures not only provide enhanced drug-like properties but also give new hits for developing leads. The synthesis of combinatorial libraries, especially with the insertion of privileged substructures into heterocyclic moieties containing nitrogen, provides for a greater probability of the discovery of novel lead compounds using chemical transformation. The review focuses on the progress in the solid-phase synthetic strategies of nitrogen containing privileged structures over the years.

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