Format

Send to

Choose Destination
Drug Metab Rev. 2013 Feb;45(1):48-59. doi: 10.3109/03602532.2012.748793.

Nuclear-receptor-mediated regulation of drug- and bile-acid-transporter proteins in gut and liver.

Author information

1
Department of Pharmacology and Toxicology, University of Kansas, Lawrence, Kansas 66045, USA. stauding@ku.edu

Abstract

Adverse drug events (ADEs) are a common cause of patient morbidity and mortality and are classically thought to result, in part, from variation in expression and activity of hepatic enzymes of drug metabolism. It is now known that alterations in the expression of genes that encode drug- and bile-acid-transporter proteins in both the gut and liver play a previously unrecognized role in determining patient drug response and eventual clinical outcome. Four nuclear receptor (NR) superfamily members, including pregnane X receptor (PXR, NR1I2), constitutive androstane receptor (NR1I3), farnesoid X receptor (NR1H4), and vitamin D receptor (NR1I1), play pivotal roles in drug- and bile-acid-activated programs of gene expression to coordinately regulate drug- and bile-acid transport activity in the intestine and liver. This review focuses on the NR-mediated gene activation of drug and bile-acid transporters in these tissues as well as the possible underlying molecular mechanisms.

PMID:
23330541
PMCID:
PMC4557796
DOI:
10.3109/03602532.2012.748793
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central
Loading ...
Support Center