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J Biol Chem. 2013 Mar 8;288(10):6968-79. doi: 10.1074/jbc.M112.431155. Epub 2013 Jan 17.

Sirtuin 1-mediated effects of exercise and resveratrol on mitochondrial biogenesis.

Author information

1
School of Kinesiology and Health Science, York University, Toronto, Ontario M3J 1P3, Canada.

Abstract

The purpose of this study was to evaluate the role of sirtuin 1 (SirT1) in exercise- and resveratrol (RSV)-induced skeletal muscle mitochondrial biogenesis. Using muscle-specific SirT1-deficient (KO) mice and a cell culture model of differentiated myotubes, we compared the treatment of resveratrol, an activator of SirT1, with that of exercise in inducing mitochondrial biogenesis. These experiments demonstrated that SirT1 plays a modest role in maintaining basal mitochondrial content and a larger role in preserving mitochondrial function. Furthermore, voluntary exercise and RSV treatment induced mitochondrial biogenesis in a SirT1-independent manner. However, when RSV and exercise were combined, a SirT1-dependent synergistic effect was evident, leading to enhanced translocation of PGC-1α and SirT1 to the nucleus and stimulation of mitochondrial biogenesis. Thus, the magnitude of the effect of RSV on muscle mitochondrial biogenesis is reliant on SirT1, as well as the cellular environment, such as that produced by repeated bouts of exercise.

PMID:
23329826
PMCID:
PMC3591607
DOI:
10.1074/jbc.M112.431155
[Indexed for MEDLINE]
Free PMC Article

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