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Circ Res. 2013 Jan 18;112(2):355-66. doi: 10.1161/CIRCRESAHA.112.268672.

Integration of troponin I phosphorylation with cardiac regulatory networks.

Author information

1
Department of Physiology and Biophysics and Center for Cardiovascular Research, University of Illinois at Chicago, College of Medicine, Chicago, IL 60612, USA. solarorj@uic.edu

Abstract

We focus here on the modulation of thin filament activity by cardiac troponin I phosphorylation as an integral and adaptive mechanism in cardiac homeostasis and as a mechanism vulnerable to maladaptive response to stress. We discuss a current concept of cardiac troponin I function in the A-band region of the sarcomere and potential signaling to cardiac troponin I in a network involving the ends of the thin filaments at the Z-disk and the M-band regions. The cardiac sarcomere represents a remarkable set of interacting proteins that functions not only as a molecular machine generating the heartbeat but also as a hub of signaling. We review how phosphorylation signaling to cardiac troponin I is integrated, with parallel signals controlling excitation-contraction coupling, hypertrophy, and metabolism.

PMID:
23329791
PMCID:
PMC3567448
DOI:
10.1161/CIRCRESAHA.112.268672
[Indexed for MEDLINE]
Free PMC Article
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