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Chin J Cancer. 2013 Sep;32(9):488-93. doi: 10.5732/cjc.012.10280. Epub 2013 Jan 18.

Small interfering RNA-based molecular therapy of cancers.

Author information

1
State Key Laboratory of Oncology in South China; Research Department, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P. R. China. dengwg@sysucc.org.cn.

Abstract

RNA interference (RNAi) has become a gold standard for validating gene function in basic life science research and provides a promising therapeutic modality for cancer and other diseases. This mini-review focuses on the potential of small interfering RNAs (siRNAs) in anticancer treatment, including the establishment and screening of cancer-associated siRNA libraries and their applications in anticancer drug target discovery and cancer therapy. This article also describes the current delivery approaches of siRNAs using lipids, polymers, and, in particular, gold nanoparticles to induce significant gene silencing and tumor growth regression.

PMID:
23327796
PMCID:
PMC3845562
DOI:
10.5732/cjc.012.10280
[Indexed for MEDLINE]
Free PMC Article

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