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J Enzyme Inhib Med Chem. 2014 Feb;29(1):1-6. doi: 10.3109/14756366.2012.742517. Epub 2013 Jan 18.

Phenolic compounds with pancreatic lipase inhibitory activity from Korean yam (Dioscorea opposita).

Author information

1
College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University , Seoul , South Korea .

Abstract

Twenty-three phenolic compounds were isolated from Dioscorea opposita by bioactivity-guided method and their inhibitory effect against pancreatic lipase was evaluated. A total of 15 isolates reduced lipase activity at IC50 values of less than 50 µM and 3,3',5-trihydroxy-2'-methoxybibenzyl showed the highest inhibition with an IC50 value of 8.8 µM. This study is a first to reveal the pancreatic lipase inhibitory activity by both D. opposita and its isolated compounds.

PMID:
23327640
DOI:
10.3109/14756366.2012.742517
[Indexed for MEDLINE]

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