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Annu Rev Med. 2013;64:277-90. doi: 10.1146/annurev-med-050311-163324.

Reprogrammed cells for disease modeling and regenerative medicine.

Author information

1
Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Manton Center for Orphan Disease Research, Howard Hughes Medical Institute, Boston, MA, USA.

Abstract

The conversion of somatic cells into pluripotent cells is transforming the way diseases are researched and treated. Induced pluripotent stem (iPS) cells' promise may soon be realized in the field of hematology, as hematopoietic stem cell transplants are already commonplace in clinics around the world. We provide a current comparison between induced pluripotent and embryonic stem cells, describe progress toward modeling hematological disorders using iPS cells, and illustrate the hurdles that must be overcome before iPS cell therapies will be available in clinics.

PMID:
23327523
PMCID:
PMC3629705
DOI:
10.1146/annurev-med-050311-163324
[Indexed for MEDLINE]
Free PMC Article

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