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World J Gastroenterol. 2013 Jan 7;19(1):8-11. doi: 10.3748/wjg.v19.i1.8.

Tumor-infiltrating B cells come into vogue.

Author information

1
Division of Molecular Oncology and Immunotherapy, Department of General Surgery, University of Rostock, D-18057 Rostock, Germany. michael.linnebacher@med.uni-rostock.de

Abstract

Lymphocyte infiltration into solid tumors has been recognized as a main determinator of positive prognosis. For the most part this is attributed to cytotoxic T cells capable of directly destroying malignant cells. However, when considering the complex composition of the human immune system, recent findings of Nielsen et al on a potentially central role of tumor-infiltrating B cells is not really surprising. In this commentary article, I want to highlight the enormous potential impact of this observation for basic and translational research, prognostic procedures and ultimately for the development of future therapeutic concepts.

KEYWORDS:

CD20+ tumor-infiltrating lymphocytes; Functional immunology; Immunotherapy; Prognosis; Tumor-infiltrating B cells

PMID:
23326156
PMCID:
PMC3542760
DOI:
10.3748/wjg.v19.i1.8
[Indexed for MEDLINE]
Free PMC Article
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