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Nature. 2013 Jan 17;493(7432):327-37. doi: 10.1038/nature11860.

Activity-dependent neuronal signalling and autism spectrum disorder.

Author information

1
Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA.

Abstract

Neuronal activity induces the post-translational modification of synaptic molecules, promotes localized protein synthesis within dendrites and activates gene transcription, thereby regulating synaptic function and allowing neuronal circuits to respond dynamically to experience. Evidence indicates that many of the genes that are mutated in autism spectrum disorder are crucial components of the activity-dependent signalling networks that regulate synapse development and plasticity. Dysregulation of activity-dependent signalling pathways in neurons may, therefore, have a key role in the aetiology of autism spectrum disorder.

PMID:
23325215
PMCID:
PMC3576027
DOI:
10.1038/nature11860
[Indexed for MEDLINE]
Free PMC Article

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