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Respirology. 2013 May;18(4):630-6. doi: 10.1111/resp.12051.

Predictors of outcome in patients with cystic fibrosis requiring endotracheal intubation.

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1
Department of Cystic Fibrosis, Royal Brompton Hospital, London, UK.

Abstract

BACKGROUND AND OBJECTIVE:

Acute severe clinical deterioration of patients with cystic fibrosis (CF) may mandate endotracheal intubation. The benefits of intubation were evaluated by examining which pre-admission parameters were associated with intensive care unit (ICU) outcome and assessing the potential benefits of intubation for survivors in terms of time from ICU discharge to death.

METHODS:

A retrospective analysis of data from a single centre was undertaken.

RESULTS:

Thirty patients required intubation on 34 occasions (8 per 1000 admissions). Eleven patients died in ICU and 7 after ICU but not hospital discharge. Fifty-nine per cent of 22 patients intubated for pneumothorax and/or haemoptysis survived to hospital discharge. Of the twelve intubated for infective exacerbations, 33% survived to hospital discharge. Those who died after hospital discharge survived 447 days. There were no significant differences for survivors in reasons for intubation, colonizing organism, frequency of infective exacerbations, severity of illness or pulmonary physiology. Osteoporosis and a greater fall in body mass index over the 24 months prior were more frequent in non-survivors.

CONCLUSIONS:

Patients with CF developing haemoptysis and/or pneumothorax should be admitted to ICU and intubated promptly, should this be required. Chronic disease markers may be more relevant prognostically than rates of hospitalization or forced expiratory volume in 1 s decline which should not be bars to invasive ventilation.

PMID:
23323684
DOI:
10.1111/resp.12051
[Indexed for MEDLINE]
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