Format

Send to

Choose Destination
See comment in PubMed Commons below
Clin Mol Hepatol. 2012 Dec;18(4):391-6. doi: 10.3350/cmh.2012.18.4.391. Epub 2012 Dec 21.

Relationship between the hepatic venous pressure gradient and first variceal hemorrhage in patients with cirrhosis: a multicenter retrospective study in Korea.

Author information

  • 1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Soonchunhyang University College of Medicine, Seoul, Korea.

Abstract

BACKGROUND/AIMS:

Variceal hemorrhage is one of the major complications of cirrhosis and is associated with significant mortality and morbidity. The development of gastroesophageal varices and variceal hemorrhage is the most direct consequence of portal hypertension. Correlations between the hepatic venous pressure gradient (HVPG) and first variceal hemorrhage were examined.

METHODS:

Patients with cirrhosis who underwent HVPG measurement between July 2009 and September 2010 were enrolled (n=535). All patients underwent esophagogastroduodenoscopy to enable the evaluation of gastroesophageal varices.

RESULTS:

The HVPG for all patients was 16.46±7.05 mmHg (mean±SD), and was significantly higher among those with first variceal hemorrhage than in those without it. The HVPG was significantly correlated with both Child-Turcotte-Pugh (r=0.488, P<0.001) and Model for End-stage Liver Disease (r=0.478, P<0.001) scores. An HVPG value of 11 mmHg was predictive of first variceal hemorrhage with a sensitivity of 92.4% and a specificity of 27.7%.

CONCLUSIONS:

The HVPG was higher in patients with first variceal hemorrhage than in those without it.

KEYWORDS:

Hepatic venous pressure gradient (HVPG); Variceal hemorrhage

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for The Korean Association for the Study of the Liver Icon for PubMed Central
    Loading ...
    Write to the Help Desk