Send to

Choose Destination
J Clin Neurol. 2012 Dec;8(4):305-7. doi: 10.3988/jcn.2012.8.4.305. Epub 2012 Dec 21.

A case of lambert-eaton myasthenic syndrome with small-cell lung cancer and transient increase in anti-acetylcholine-receptor-binding antibody titer.

Author information

Department of Neurology, Yonsei University College of Medicine, Seoul, Korea. ; Department of Neurology, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea.



Lambert-Eaton myasthenic syndrome (LEMS) is a presynaptic neuromuscular junction disorder that is most frequently associated with small-cell lung cancer (SCLC). The titers of antibodies against voltage-gated calcium channels are frequently increased in LEMS, but only rarely is titer of anti-acetylcholine-receptor-binding antibodies (AChR-abs) increased.


A 57-year-old male was admitted to our hospital due to dry mouth and eyes and progressive proximal limb weakness of 2 months duration. The results of a repetitive nerve stimulation test disclosed all criteria for the electrophysiological LEMS pattern, and the patient's AChR-abs titer was 0.587 nmol/L. At a follow-up performed 5 years after successful treatment of SCLC and LEMS, his AChR-abs titer had decreased to 0.001 nmol/L.


We suggest that this was a case of transient pseudopositivity of AChR-abs in SCLC with LEMS.


Lambert-Eaton myasthenic syndrome; myasthenia gravis; small-cell lung carcinoma

Supplemental Content

Full text links

Icon for Korean Neurological Association Icon for PubMed Central
Loading ...
Support Center