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Korean J Radiol. 2013 Jan-Feb;14(1):102-9. doi: 10.3348/kjr.2013.14.1.102. Epub 2012 Dec 28.

Preliminary experience using dynamic MRI at 3.0 Tesla for evaluation of soft tissue tumors.

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  • 1Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea.

Abstract

OBJECTIVE:

We aimed to evaluate the use of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) at 3.0 T for differentiating the benign from malignant soft tissue tumors. Also we aimed to assess whether the shorter length of DCE-MRI protocols are adequate, and to evaluate the effect of temporal resolution.

MATERIALS AND METHODS:

Dynamic contrast-enhanced magnetic resonance imaging, at 3.0 T with a 1 second temporal resolution in 13 patients with pathologically confirmed soft tissue tumors, was analyzed. Visual assessment of time-signal curves, subtraction images, maximal relative enhancement at the first (maximal peak enhancement [Emax]/1) and second (Emax/2) minutes, Emax, steepest slope calculated by using various time intervals (5, 30, 60 seconds), and the start of dynamic enhancement were analyzed.

RESULTS:

The 13 tumors were comprised of seven benign and six malignant soft tissue neoplasms. Washout on time-signal curves was seen on three (50%) malignant tumors and one (14%) benign one. The most discriminating DCE-MRI parameter was the steepest slope calculated, by using at 5-second intervals, followed by Emax/1 and Emax/2. All of the steepest slope values occurred within 2 minutes of the dynamic study. Start of dynamic enhancement did not show a significant difference, but no malignant tumor rendered a value greater than 14 seconds.

CONCLUSION:

The steepest slope and early relative enhancement have the potential for differentiating benign from malignant soft tissue tumors. Short-length rather than long-length DCE-MRI protocol may be adequate for our purpose. The steepest slope parameters require a short temporal resolution, while maximal peak enhancement parameter may be more optimal for a longer temporal resolution.

KEYWORDS:

Dynamic contrast enhanced MRI; MRI; Maximal peak enhancement; Maximal relative enhancement; Soft tissue tumor; Time signal intensity curve

PMID:
23323039
PMCID:
PMC3542292
DOI:
10.3348/kjr.2013.14.1.102
[PubMed - indexed for MEDLINE]
Free PMC Article
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