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Viruses. 2013 Jan 15;5(1):182-91. doi: 10.3390/v5010182.

Insights into the roles of cyclophilin A during influenza virus infection.

Author information

1
Center for Molecular Virology, Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China. xiaolingliu03@163.com

Abstract

Cyclophilin A (CypA) is the main member of the immunophilin superfamily that has peptidyl-prolyl cis-trans isomerase activity. CypA participates in protein folding, cell signaling, inflammation and tumorigenesis. Further, CypA plays critical roles in the replication of several viruses. Upon influenza virus infection, CypA inhibits viral replication by interacting with the M1 protein. In addition, CypA is incorporated into the influenza virus virions. Finally, Cyclosporin A (CsA), the main inhibitor of CypA, inhibits influenza virus replication through CypA-dependent and -independent pathways. This review briefly summarizes recent advances in understanding the roles of CypA during influenza virus infection.

PMID:
23322171
PMCID:
PMC3564116
DOI:
10.3390/v5010182
[Indexed for MEDLINE]
Free PMC Article

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