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J Comput Assist Tomogr. 2013 Jan-Feb;37(1):91-7. doi: 10.1097/RCT.0b013e3182752967.

Craniofacial bone infarcts in sickle cell disease: clinical and radiological manifestations.

Author information

1
Department of Radiology, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118, USA. memimd@hotmail.com

Abstract

OBJECTIVE:

To investigate the clinicoradiological manifestations of craniofacial bone infarcts in patients with sickle cell disease (SCD).

MATERIALS AND METHODS:

After institutional review board approval, we identified 85 SCD patients who underwent head and neck magnetic resonance imaging (MRI) during a period of 5 years (January 1, 2004-December 31, 2008) and reviewed their clinical presentations and radiological findings.

RESULTS:

Of 40 subjects with headache or facial pain, 6 (5 males, 1 female; age range, 2-22 years; 5 Hb SS, 1 Hb SC) were diagnosed with acute bone infarct by MRI. Of these 6, 4 demonstrated infarcts in the mandible. Magnetic resonance images showed bone marrow edema, subperiosteal fluid collections with susceptibility effects suggesting associated hemorrhage, and heterogeneous enhancement.

CONCLUSIONS:

Acute craniofacial bone infarcts were found in 7% of SCD patients who underwent MRI and in 15% of SCD patients who presented with pain. The MRI showed characteristic imaging findings including marrow edema, subperiosteal hematoma, and heterogeneous enhancement.

PMID:
23321839
DOI:
10.1097/RCT.0b013e3182752967
[Indexed for MEDLINE]

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