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Nat Rev Microbiol. 2013 Feb;11(2):115-28. doi: 10.1038/nrmicro2950.

West Nile virus infection and immunity.

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Department of Immunology, University of Washington, School of Medicine, 1959 NE Pacific Street, Seattle, Washington 98195, USA.


West Nile virus (WNV) is an emerging neurotropic flavivirus that is transmitted to humans through the bite of an infected mosquito. WNV has disseminated broadly in the Western hemisphere and now poses a significant public health risk. The continuing spread of WNV, combined with the lack of specific therapeutics or vaccines to combat or prevent infection, imparts a pressing need to identify the viral and host processes that control the outcome of and immunity to WNV infection. Here, we provide an overview of recent research that has revealed the virus-host interface controlling WNV infection and immunity.

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