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Cell Biosci. 2013 Jan 15;3(1):4. doi: 10.1186/2045-3701-3-4.

TGF-beta1 on osteoimmunology and the bone component cells.

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Mucosal Immunology Section, NIDCR, NIH, Bethesda, MD, USA.


TGF-β1 is an immunoregulatory cytokine that regulates immune cell proliferation, survival, differentiation, and migration. Compelling evidence has demonstrated a strong association between the immune and skeletal systems (so called Osteoimmunology), such as the critical role of TGF-β1 in the development and maintenance of the skeletal tissue. This review provides an overview of the mechanisms in which TGF-β1 interacts with bone component cells, such as osteoblasts, osteoclasts, chondrocytes, mesenchymal stem cells, and hematopoietic stem cells, in concert with other cytokines and hormones.

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