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Mol Pharm. 2013 Mar 4;10(3):1063-9. doi: 10.1021/mp300549d. Epub 2013 Feb 4.

Collagen stimulating effect of peptide amphiphile C16-KTTKS on human fibroblasts.

Author information

1
School of Chemistry, Food and Pharmacy, University of Reading , Reading RG6 6AD, U.K.

Abstract

The collagen production of human dermal and corneal fibroblasts in contact with solutions of the peptide amphiphile (PA) C16-KTTKS is investigated and related to its self-assembly into nanotape structures. This PA is used in antiwrinkle cosmeceutical applications (trade name Matrixyl). We prove that C16-KTTKS stimulates collagen production in a concentration-dependent manner close to the critical aggregation concentration determined from pyrene fluorescence spectroscopy. This suggests that self-assembly and the stimulation of collagen production are inter-related.

PMID:
23320752
DOI:
10.1021/mp300549d
[Indexed for MEDLINE]

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