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Cancer Discov. 2013 Jan;3(1):24-6. doi: 10.1158/2159-8290.CD-12-0521.

Mutant and wild-type Ras: co-conspirators in cancer.

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1
Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

Abstract

Although the functional interplay between mutant and wild-type Ras in driving tumor initiation and growth has been described, a clear picture of the precise ramifications and mechanisms of this association remains elusive, sometimes with conflicting conclusions. A report in this issue of Cancer Discovery tackles this question, which may have important implications for therapeutic strategies to block mutant Ras for cancer treatment.

PMID:
23319767
PMCID:
PMC3808242
DOI:
10.1158/2159-8290.CD-12-0521
[Indexed for MEDLINE]
Free PMC Article
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