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Oncogene. 2014 Jan 16;33(3):308-15. doi: 10.1038/onc.2012.596. Epub 2013 Jan 14.

TRIM3, a tumor suppressor linked to regulation of p21(Waf1/Cip1.).

Author information

1
Programs in Molecular Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
2
Human Oncology and Pathogenesis, New York, NY, USA.
3
Cancer Biology, New York, NY, USA.
4
Computational Biology. Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Abstract

The TRIM family of genes is largely studied because of their roles in development, differentiation and host cell antiviral defenses; however, roles in cancer biology are emerging. Loss of heterozygosity of the TRIM3 locus in ∼20% of human glioblastomas raised the possibility that this NHL-domain containing member of the TRIM gene family might be a mammalian tumor suppressor. Consistent with this, reducing TRIM3 expression increased the incidence of and accelerated the development of platelet-derived growth factor -induced glioma in mice. Furthermore, TRIM3 can bind to the cdk inhibitor p21(WAF1/CIP1). Thus, we conclude that TRIM3 is a tumor suppressor mapping to chromosome 11p15.5 and that it might block tumor growth by sequestering p21 and preventing it from facilitating the accumulation of cyclin D1-cdk4.

PMID:
23318451
PMCID:
PMC3928554
DOI:
10.1038/onc.2012.596
[Indexed for MEDLINE]
Free PMC Article

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