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Biochem Biophys Res Commun. 2013 Feb 15;431(3):586-9. doi: 10.1016/j.bbrc.2012.12.139. Epub 2013 Jan 11.

D5 dopamine receptor carboxyl tail involved in D5-D2 heteromer formation.

Author information

1
Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada M5S 1A8. brian.odowd@utoronto.ca

Abstract

We have demonstrated that D(5) and D(2) dopamine receptors exist as heteromers in cells, and determined these receptor interact through amino acids in the cytoplasmic regions of each receptor. Specifically involved in heteromer formation we identified in the carboxyl tail of the D(5) receptor three adjacent glutamic acid residues, and in intracellular loop 3 of the D(2) receptor two adjacent arginine residues. Any pairing of these three D(5) receptor glutamic acids were sufficient for heteromer formation. These identified residues in D(5) and D(2) receptors are oppositely charged and likely interact by electrostatic interactions.

PMID:
23318175
PMCID:
PMC3744868
DOI:
10.1016/j.bbrc.2012.12.139
[Indexed for MEDLINE]
Free PMC Article

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