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Gynecol Endocrinol. 2013 Apr;29(4):380-3. doi: 10.3109/09513590.2012.752453. Epub 2013 Jan 15.

Ultrasonographic assessment of skin thickness in patients with PCOS - a case-control study.

Author information

1
Department of Gynecological Endocrinology and Reproductive Medicine, Innsbruck Medical University, Innsbruck, Austria.

Abstract

OBJECTIVE:

To measure skin thickness in patients with polycystic ovary syndrome (PCOS) in comparison to controls and to examine a possible association with sex steroids, body mass index, lipid profile and hyperinsulinemia.

METHODS:

Thirty patients with confirmed PCOS were compared to thirty-two women presenting for infertility workup. Skin thickness was measured using high-resolution ultrasound in a standardized area, blood samples were collected once at presentation.

RESULTS:

Patients with PCOS showed a statistically significant thicker skin than women in the control group (0.95 mm (±0.093 mm) versus 0.85 mm (±0.077 mm, p < 0.0001)). LH, estradiol, testosterone, the free androgen index, triglycerides, cholesterol, LDL-cholesterol and body mass index were significantly increased in PCOS - patients. No correlation between hyperinsulinemia and skin thickness was seen.

CONCLUSIONS:

PCOS - patients showed a greater skin thickness in comparison to women without PCOS. This might be due to proliferative effects of sex steroids such as estrogens and testosterone and metabolic derangements on skin thickness.

PMID:
23316887
DOI:
10.3109/09513590.2012.752453
[Indexed for MEDLINE]

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