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Stem Cells Int. 2012;2012:926147. doi: 10.1155/2012/926147. Epub 2012 Dec 20.

Parkinson's Disease in a Dish: What Patient Specific-Reprogrammed Somatic Cells Can Tell Us about Parkinson's Disease, If Anything?

Author information

  • 1Neuroscience Axis, CHUL Research Center (CHUQ), T2-50, 2705 Boul. Laurier, Quebec City, QC, Canada G1V 4G2.

Abstract

Technologies allowing for the derivation of patient-specific neurons from somatic cells are emerging as powerful in vitro tools to investigate the intrinsic cellular pathological behaviours of the diseases that affect these patients. While the use of patient-derived neurons to model Parkinson's disease (PD) has only just begun, these approaches have allowed us to begin investigating disease pathogenesis in a unique way. In this paper, we discuss the advances made in the field of cellular reprogramming to model PD and discuss the pros and cons associated with the use of such cells.

PMID:
23316244
PMCID:
PMC3539381
DOI:
10.1155/2012/926147
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