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Nat Chem Biol. 2013 Mar;9(3):160-2. doi: 10.1038/nchembio.1164. Epub 2013 Jan 13.

An unsaturated aliphatic alcohol as a natural ligand for a mouse odorant receptor.

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1
Department of Applied Biological Chemistry, The University of Tokyo, Tokyo, Japan.

Abstract

We report the identification of a physiological receptor-volatile pair in the mouse olfactory system. By activity-guided fractionation of exocrine gland extracts and subsequent chemical analysis, (Z)-5-tetradecen-1-ol was identified as a natural ligand for a mouse odorant receptor. (Z)-5-tetradecen-1-ol is excreted into male mouse urine under androgen control and enhances urine attractiveness to female mice. This report is to our knowledge the first to describe natural product-based deorphanization of an odorant receptor.

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PMID:
23314914
DOI:
10.1038/nchembio.1164
[Indexed for MEDLINE]
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