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Gastroenterology. 2013 Mar;144(3):512-27. doi: 10.1053/j.gastro.2013.01.002. Epub 2013 Jan 9.

Role of the microenvironment in the pathogenesis and treatment of hepatocellular carcinoma.

Author information

1
Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA.

Abstract

Hepatocellular carcinoma (HCC) is the most common primary liver tumor and the third greatest cause of cancer-related death worldwide, and its incidence is increasing. Despite the significant improvement in management of HCC over the past 30 years, there are no effective chemoprevention strategies, and only one systemic therapy has been approved for patients with advanced tumors. This drug, sorafenib, acts on tumor cells and the stroma. HCC develops from chronically damaged tissue that contains large amounts of inflammation and fibrosis, which also promote tumor progression and resistance to therapy. Increasing our understanding of how stromal components interact with cancer cells and the signaling pathways involved could help identify new therapeutic and chemopreventive targets.

PMID:
23313965
PMCID:
PMC3578068
DOI:
10.1053/j.gastro.2013.01.002
[Indexed for MEDLINE]
Free PMC Article

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