Format

Send to

Choose Destination
Curr Opin Microbiol. 2013 Feb;16(1):93-9. doi: 10.1016/j.mib.2012.12.001. Epub 2013 Jan 9.

Microbial amyloids--functions and interactions within the host.

Author information

1
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, United States.

Abstract

The aggregation of proteins into amyloid fibers is a common characteristic of many neurodegenerative disorders including Alzheimer's, Parkinson's, and prion diseases. Amyloid formation was originally characterized in these systems and is traditionally viewed as a consequence of protein misfolding and aggregation. An emerging field of study brings functional amyloids, like those produced by bacteria, into the scientific mainstream, and demonstrates a ubiquitous role for amyloids in living systems. This review aims to summarize what is known about the bacterial amyloids and their interactions within various host environments.

PMID:
23313395
PMCID:
PMC3622111
DOI:
10.1016/j.mib.2012.12.001
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center