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Am J Obstet Gynecol. 2013 Jun;208(6):484.e1-6. doi: 10.1016/j.ajog.2013.01.011. Epub 2013 Jan 10.

Turner's syndrome and other forms of congenital hypogonadism impair quality of life and sexual function.

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1
Unit of Endocrinological Gynecology, Department of Gynecology, Institut Clinic de Ginecologia, Obstetricia i Neonatologia, Hospital Clínic, Universitat de Barcelona, Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Catalunya, Spain.

Abstract

OBJECTIVE:

We sought to assess the burden of Turner's syndrome (TS) and other congenital hypogonadisms (OCH) on quality of life (QOL) and sexual function.

STUDY DESIGN:

An observational study was undertaken in a gynecological endocrinology unit of a teaching hospital. Three cohorts of women aged 20-50 years were compared: 26 TS patients, 21 women with OCH and wild-type karyotype, and 41 healthy age-matched women who were included as controls. All subjects filled out the Medical Outcome Study Short Form (SF-36) and the Female Sexual Function Index.

RESULTS:

TS subjects had significantly worse QOL scores in physical functioning (P = .026) and role physical functioning (P = .032) whereas OCH showed significantly worse scores in physical functioning (P = .027) and bodily pain (P = .025) compared to controls. In all, 80% of OCH and 50% of TS patients declared sexual activity. Sexually active TS patients had poorer arousal outcomes (P = .009) and OCH women showed significantly worse scores in arousal (P = .002), orgasm (P = .007), pain (P = .001), and Female Sexual Function Index total score (P = .004) compared with healthy controls. No differences between sexually active and inactive TS women were found in SF-36 scores, clinical characteristics, or anthropomorphic characteristics.

CONCLUSION:

TS and OCH subjects presented impaired physical domains in QOL. Women with TS are less likely to be involved in sexual activity, arousal dysfunctions being their main symptom. Conversely, arousal, orgasm, pain, and total score were significantly affected in OCH subjects.

PMID:
23313313
DOI:
10.1016/j.ajog.2013.01.011
[Indexed for MEDLINE]
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