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FEBS Lett. 2013 Feb 14;587(4):311-6. doi: 10.1016/j.febslet.2012.12.016. Epub 2013 Jan 8.

Ubiquitin-specific protease 4 promotes TNF-α-induced apoptosis by deubiquitination of RIP1 in head and neck squamous cell carcinoma.

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1
Department of Otorhinolaryngology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China.

Abstract

Head and neck squamous cell carcinoma (HNSCC) is a common type of cancer. Better understanding of molecular aberrations associated with HNSCC might identify new diagnostic and therapeutic strategies for this disease. In this study, we found ubiquitin-specific protease 4 (USP4) was significantly upregulated in HNSCC. USP4 negatively regulates RIP1-mediated NF-κB activation and promotes TNF-α-induced apoptosis in FaDu cells. USP4 directly interacts with receptor-interacting protein 1 (RIP1) and deubiquitinates K63-linked ubiquitination from RIP1. Therefore, our results indicate that USP4 has tumor suppressor roles in HNSCC and suggest USP4 as a potential therapeutic target for HNSCC.

PMID:
23313255
DOI:
10.1016/j.febslet.2012.12.016
[Indexed for MEDLINE]
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