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Bioorg Med Chem Lett. 2013 Feb 15;23(4):1051-5. doi: 10.1016/j.bmcl.2012.12.028. Epub 2012 Dec 20.

Optimization of highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase.

Author information

1
Pfizer Global Research & Development, Michigan Laboratories, Ann Arbor, MI 48105, USA. napowell@comcast.net

Abstract

Optimization of the ADME properties of a series of 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase resulted in the identification of highly selective compounds with properties suitable for use as in vitro and in vivo tools to probe the effects of Sky inhibition.

PMID:
23312943
DOI:
10.1016/j.bmcl.2012.12.028
[Indexed for MEDLINE]

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