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Leuk Res. 2013 Apr;37(4):367-71. doi: 10.1016/j.leukres.2012.12.008. Epub 2013 Jan 9.

Endocrine sequelae and metabolic syndrome in adult long-term survivors of childhood acute myeloid leukemia.

Author information

1
Department of Pediatric Oncology/Hematology, Erasmus MC-Sophia Children's Hospital Rotterdam, Rotterdam, The Netherlands. k.blijdorp@erasmusmc.nl

Abstract

This study focuses on the effect of chemotherapy on endocrinopathies and the metabolic syndrome in adult survivors of childhood acute myeloid leukemia (AML). Endocrine function and metabolic syndrome were evaluated in 12 AML survivors, treated with chemotherapy, and in 9 survivors of myeloid leukemias treated with stem cell transplantation (SCT), after a median follow-up time of 20 years (range 9-31). In survivors treated with chemotherapy, no endocrinopathies or metabolic syndrome were present, although AMH and Inhibin B levels tended to be lower than in controls. In SCT survivors, pituitary deficiencies and metabolic syndrome were more frequent.

PMID:
23312900
DOI:
10.1016/j.leukres.2012.12.008
[Indexed for MEDLINE]

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