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Allergol Immunopathol (Madr). 2014 Jan-Feb;42(1):19-21. doi: 10.1016/j.aller.2012.07.008. Epub 2013 Jan 9.

Serum level of zinc in asthmatic patients: a case-control study.

Author information

1
Department of Pediatric Respiratory Diseases, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: khanbabaeegh@yahoo.com.
2
Department of Pediatric Diseases, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3
Department of Pediatric Gastrointestinal Diseases, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
4
Department of Microbiology, Faculty of Biological Sciences, Shahid Beheshti University, Tehran, Iran.
5
Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Molecular Immunology Research Center; and Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

BACKGROUND:

Hypozincemia could lead to a variety of defects in growth and the immune system, while it seems to be associated with increased rate of asthmatic attacks in children.

METHODS:

This study was performed to assess the serum zinc level in 100 paediatric asthmatic patients in comparison with a control group.

RESULTS:

Mean serum level of zinc in the asthmatic patients was 70.5±22.6 μg/dL, which was significantly lower than 80.9±16.9 μg/dL in the control group (p<0.001). Forty-two asthmatic patients (42%) had hypozincemia, while this rate was 12% in healthy children (p<0.001). There was a significant association between the zinc level and severity of asthma (p<0.001). However, no significant association was detected between the serum level of zinc and other factors, including control and treatment of the disease.

CONCLUSIONS:

As for high rate of hypozincemia in the asthmatic children, evaluation of serum zinc level in asthmatic children could be suggested, while zinc substitution in the diet of those with hypozincemia could be recommended.

KEYWORDS:

Asthma; Children; Zinc

PMID:
23312452
DOI:
10.1016/j.aller.2012.07.008
[Indexed for MEDLINE]

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