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J Enzyme Inhib Med Chem. 2014 Feb;29(1):35-42. doi: 10.3109/14756366.2012.750311. Epub 2013 Jan 12.

Carbonic anhydrase inhibitory properties of novel sulfonamide derivatives of aminoindanes and aminotetralins.

Author information

1
Faculty of Science, Department of Chemistry, Atatürk University , Erzurum , Turkey .

Abstract

Six sulfonamides derived from indanes and tetralines were synthesized. The human carbonic anhydrase isozymes hCA I and hCA II inhibition effects of the synthesized sulfonamides were determined. From these compounds, while N-(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methane sulfonamide showed the most potent inhibitory effect against hCA I (Ki=46 ± 5.4 µM, r(2) =0.978), N-(1,2,3,4-tetrahydronaphthalene-2-yl)methanesulfonamide was found to have the best inhibitory effect against hCA II (Ki=94 ± 7.6 µM, r(2) =0.982).

PMID:
23311862
DOI:
10.3109/14756366.2012.750311
[Indexed for MEDLINE]

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