Format

Send to

Choose Destination
Science. 2013 Jan 11;339(6116):156-61. doi: 10.1126/science.1227901.

Microglia: scapegoat, saboteur, or something else?

Author information

1
Institute of Neuropathology, University Hospital Zurich, Schmelzbergstrasse 12, CH-8012 Zurich, Switzerland. adriano.aguzzi@usz.ch

Abstract

Microglia are resident immune cells in the brain and spinal cord. These cells provide immune surveillance and are mobilized in response to disparate diseases and injuries. Although microglial activation is often considered neurotoxic, microglia are essential defenders against many neurodegenerative diseases. It also seems increasingly likely that microglial dysfunction can underlie certain neurological diseases without an obvious immune component.

PMID:
23307732
PMCID:
PMC4431634
DOI:
10.1126/science.1227901
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center