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Nutrients. 2013 Jan 10;5(1):97-110. doi: 10.3390/nu5010097.

Selenium in bone health: roles in antioxidant protection and cell proliferation.

Author information

1
Grand Forks Human Nutrition Research Center, Agricultural Research Service, United States Department of Agriculture, Grand Forks, ND 58202, USA. huawei.zeng@ars.usda.gov

Abstract

Selenium (Se) is an essential trace element for humans and animals, and several findings suggest that dietary Se intake may be necessary for bone health. Such findings may relate to roles of Se in antioxidant protection, enhanced immune surveillance and modulation of cell proliferation. Elucidation of the mechanisms by which Se supports these cellular processes can lead to a better understanding of the role of this nutrient in normal bone metabolism. This article reviews the current knowledge concerning the molecular functions of Se relevant to bone health.

PMID:
23306191
PMCID:
PMC3571640
DOI:
10.3390/nu5010097
[Indexed for MEDLINE]
Free PMC Article

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