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J Appl Physiol (1985). 2013 Apr;114(7):834-43. doi: 10.1152/japplphysiol.00950.2012. Epub 2013 Jan 10.

Airway smooth muscle in the pathophysiology and treatment of asthma.

Author information

1
Department of Medicine, University of Chicago, Chicago, IL, USA. diana.doeing@uchospitals.edu

Abstract

Airway smooth muscle (ASM) plays an integral part in the pathophysiology of asthma. It is responsible for acute bronchoconstriction, which is potentiated by constrictor hyperresponsiveness, impaired relaxation and length adaptation. ASM also contributes to airway remodeling and inflammation in asthma. In light of this, ASM is an important target in the treatment of asthma.

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PMID:
23305987
PMCID:
PMC3633438
DOI:
10.1152/japplphysiol.00950.2012
[Indexed for MEDLINE]
Free PMC Article

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