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Clin Dev Immunol. 2012;2012:606195. doi: 10.1155/2012/606195. Epub 2012 Dec 6.

Clinical and pathological roles of Ro/SSA autoantibody system.

Author information

1
Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Yokohama 236-0004, Japan. yoshiryu@med.yokohama-cu.ac.jp

Abstract

Anti-Ro/SSA antibodies are among the most frequently detected autoantibodies against extractable nuclear antigens and have been associated with systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). Although the presence of these autoantibodies is one of the criteria for the diagnosis and classification of SS, they are also sometimes seen in other systemic autoimmune diseases. In the last few decades, the knowledge of the prevalence of anti-Ro/SSA antibodies in various autoimmune diseases and symptoms has been expanded, and the clinical importance of these antibodies is increasing. Nonetheless, the pathological role of the antibodies is still poorly understood. In this paper, we summarize the milestones of the anti-Ro/SSA autoantibody system and provide new insights into the association between the autoantibodies and the pathogenesis of autoimmune diseases.

PMID:
23304190
PMCID:
PMC3523155
DOI:
10.1155/2012/606195
[Indexed for MEDLINE]
Free PMC Article

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