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Case Rep Med. 2012;2012:497362. doi: 10.1155/2012/497362. Epub 2012 Dec 4.

Malignant transformation of endometrioma in a woman with a history of ovulation induction and in vitro fertilization.

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School of Medicine, Wayne State University, 60 West Hancock Street, Detroit, MI 48201, USA.


Our aim is to document a case of endometrioid adenocarcinoma of the ovary found in an endometriotic cyst that was suspected on pelvic ultrasound in a patient with polycystic ovary syndrome, normal Ca125, and a recent history of ovulation induction for IVF. She underwent an exploratory laparotomy with left salpingo-oophorectomy and omental biopsies followed by reexploration, complete staging, and modified radical abdominal hysterectomy and right salpingo-oophorectomy. An endometrioma described as suspicious for malignancy by an experienced ultrasound examiner should prompt immediate referral to a gynecological oncologist irrespective of Ca125 levels especially in women with a history of ovulation induction and endometriosis.

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