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Mediators Inflamm. 2012;2012:846052. doi: 10.1155/2012/846052. Epub 2012 Dec 6.

Association between polymorphisms in interleukin-17A and -17F genes and chronic periodontal disease.

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1
Departmento de Clínica, Patologia e Cirurgia Odontológicas, Faculdade de Odontologia, Universidade Federal de Minas Gerais, 31.270-901 Belo Horizonte, MG, Brazil.

Abstract

OBJECTIVE:

Interleukin-17 (IL-17) is a cytokine that induces neutrophil recruitment and the release of inflammatory mediators in several inflammatory conditions; nevertheless, the involvement of IL-17 gene polymorphisms in chronic periodontitis (CP) has not been addressed yet. Our aim was to evaluate the association between periodontal status and the polymorphisms IL-17A G197A and IL-17F C7488T in subjects with CP along with their impact on levels of inflammatory mediators.

MATERIAL AND METHODS:

Genomic DNA was obtained from 30 CP patients and 30 healthy controls (HCs). IL-17A G197A and IL-17F C7488T polymorphisms were determined using PCR-RFLP. Serum and periodontal tissues were collected and processed for ELISA, myeloperoxidase (MPO), and/or microscopic analysis.

RESULTS:

The frequencies of genotypes in the CP group were significantly different from those of HC. Odds ratio indicated that increased risks for CP were associated with the -197A allele, not with the -7488T allele. In addition, the -197A allele was correlated with worse clinical parameters, higher MPO activity, and increased expression of inflammatory mediators (IL-17A and IL-8) than the other genotypes.

CONCLUSIONS:

These results indicate that the IL-17A -197A allele is associated with increased risk for CP, likely because this genotype relates to the enhanced inflammation in periodontal tissues.

PMID:
23304063
PMCID:
PMC3523166
DOI:
10.1155/2012/846052
[Indexed for MEDLINE]
Free PMC Article
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