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Neurology. 2013 Jan 29;80(5):492-5. doi: 10.1212/WNL.0b013e31827f0ebb. Epub 2013 Jan 9.

Decreased iron levels in the temporal cortex in postmortem human brains with Parkinson disease.

Author information

1
Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines, Physiology, Medical College of Qingdao University, Qingdao, China.

Abstract

OBJECTIVE:

The present study aimed to evaluate alterations in the levels of iron, divalent metal transporter 1 (DMT1) with the iron-responsive element (IRE), transferrin receptor 1 (TfR1), ferroportin 1 (FPN1), and iron regulatory protein 1 (IRP1) in the temporal cortex of human brains with Parkinson disease (PD).

METHODS:

Iron content was measured using an ICP-MS 7500CE detector. IRP1, DMT1+IRE, TfR1, and FPN1 expressions were determined by Western blotting.

RESULTS:

Iron content was significantly lower in the temporal cortex of patients with PD when compared with age-matched healthy controls. Unexpectedly, the levels of DMT1+IRE, TfR1, FPN1, and IRP1 were decreased in the temporal cortex in PD brains. No changes were observed in the temporal cortex of postmortem Alzheimer disease brains.

CONCLUSIONS:

Iron deprivation and iron-related protein dysregulation suggest that a different iron regulatory mechanism may exist, and that iron redistribution may occur between the temporal cortex and the substantia nigra of patients with PD.

PMID:
23303856
PMCID:
PMC3590051
DOI:
10.1212/WNL.0b013e31827f0ebb
[Indexed for MEDLINE]
Free PMC Article
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