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Biofactors. 2013 Jan-Feb;39(1):122-32. doi: 10.1002/biof.1063. Epub 2013 Jan 10.

Curcumin and neurodegenerative diseases.

Author information

1
Dirección de Investigación, Hospital General de México, México D. F., México.

Abstract

Over the last 10 years curcumin has been reported to be effective against a wide variety of diseases and is characterized as having anticarcinogenic, hepatoprotective, thrombosuppressive, cardioprotective, antiarthritic, and anti-infectious properties. Recent studies performed in both vertebrate and invertebrate models have been conducted to determine whether curcumin was also neuroprotective. The efficacy of curcumin in several preclinical trials for neurodegenerative diseases has created considerable excitement mainly because of its lack of toxicity and low cost. This suggests that curcumin could be a worthy candidate for nutraceutical intervention. As aging is a common risk factor for neurodegenerative diseases, it is possible that some compounds that target aging mechanisms could also prevent these kinds of diseases. One potential mechanism to explain several of the general health benefits associated with curcumin is that it may prevent aging-associated changes in cellular proteins that lead to protein insolubility and aggregation. This loss in protein homeostasis is associated with several age-related diseases. Recently, curcumin has been found to help maintain protein homeostasis and extend lifespan in the model invertebrate Caenorhabditis elegans. Here, we review the evidence from several animal models that curcumin improves healthspan by preventing or delaying the onset of various neurodegenerative diseases.

PMID:
23303664
PMCID:
PMC3578106
DOI:
10.1002/biof.1063
[Indexed for MEDLINE]
Free PMC Article
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