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Pediatr Blood Cancer. 2013 May;60(5):728-33. doi: 10.1002/pbc.24464. Epub 2013 Jan 9.

Epidemiology of childhood acute myeloid leukemia.

Author information

1
Center for Health Outcomes and Prevention Research, Sanford Research, Sioux Falls, South Dakota 57104, USA. susan.puumala@sanfordhealth.org

Abstract

Although leukemia is the most common childhood cancer diagnosis, the subtype, acute myeloid leukemia (AML), is less common and fewer etiologic studies exist. This review summarizes the major risk factors for AML. We searched the literature using PubMed for articles on childhood AML and reviewed 180 articles. While few risk factors are definitive, we identified several with consistent evidence of a possible effect. Thorough analysis of genetic and epigenetic factors is missing from this literature and methodological issues are unresolved. Future studies should more closely examine causal mechanisms, improve exposure measurement, and include analysis using genetic and epigenetic factors.

PMID:
23303597
PMCID:
PMC3664189
DOI:
10.1002/pbc.24464
[Indexed for MEDLINE]
Free PMC Article
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